Reviewing Zynerba Pharmaceuticals (ZYNE) & BeyondSpring (BYSI)

Zynerba Pharmaceuticals (NASDAQ: ZYNE) and BeyondSpring (NASDAQ:BYSI) are both small-cap medical companies, but which is the superior investment? We will contrast the two businesses based on the strength of their analyst recommendations, risk, valuation, dividends, earnings, profitability and institutional ownership.

Analyst Recommendations

This is a breakdown of recent ratings and target prices for Zynerba Pharmaceuticals and BeyondSpring, as reported by MarketBeat.

Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Zynerba Pharmaceuticals 0 5 4 0 2.44
BeyondSpring 0 0 3 0 3.00

Zynerba Pharmaceuticals presently has a consensus price target of $15.13, suggesting a potential upside of 8.97%. BeyondSpring has a consensus price target of $54.00, suggesting a potential upside of 53.19%. Given BeyondSpring’s stronger consensus rating and higher possible upside, analysts clearly believe BeyondSpring is more favorable than Zynerba Pharmaceuticals.

Earnings and Valuation

This table compares Zynerba Pharmaceuticals and BeyondSpring’s gross revenue, earnings per share and valuation.

Gross Revenue Price/Sales Ratio NetIncome Earnings Per Share Price/Earnings Ratio
Zynerba Pharmaceuticals $10,000.00 18,807.40 -$23.38 million ($2.58) -5.38
BeyondSpring N/A N/A -$12.01 million N/A N/A

BeyondSpring has higher revenue, but lower earnings than Zynerba Pharmaceuticals.

Profitability

This table compares Zynerba Pharmaceuticals and BeyondSpring’s net margins, return on equity and return on assets.

Net Margins Return on Equity Return on Assets
Zynerba Pharmaceuticals N/A -50.64% -45.05%
BeyondSpring N/A N/A N/A

Insider and Institutional Ownership

34.7% of Zynerba Pharmaceuticals shares are owned by institutional investors. Comparatively, 1.2% of BeyondSpring shares are owned by institutional investors. 10.0% of Zynerba Pharmaceuticals shares are owned by insiders. Strong institutional ownership is an indication that large money managers, hedge funds and endowments believe a company is poised for long-term growth.

Summary

BeyondSpring beats Zynerba Pharmaceuticals on 5 of the 9 factors compared between the two stocks.

About Zynerba Pharmaceuticals

Zynerba Pharmaceuticals, Inc. is a specialty pharmaceutical company. The Company is engaged in developing and commercializing transdermal synthetic cannabinoid treatments for patients with high unmet needs. Its development pipeline includes two product candidates: ZYN002 and ZYN001. ZYN002 is a synthetic cannabidiol (CBD), which is a non-psychoactive cannabinoid, formulated as a patent-protected permeation-enhanced gel for transdermal delivery through the skin and into the circulatory system. ZYN002 is in Phase II clinical development in patients with refractory epilepsy, in patients with osteoarthritis of the knee, as well as in patients with Fragile X syndrome. ZYN001 is a pro-drug of tetrahydrocannabinol (THC) that enables transdermal delivery through the skin and into the circulatory system through a patch. ZYN001 is targeting two pain indications, fibromyalgia and peripheral neuropathic pain.

About BeyondSpring

BeyondSpring Inc. is a global clinical-stage biopharmaceutical company. The Company is focused on the development of cancer therapies. The Company is engaged in advancing its lead product, Plinabulin, into a Phase II/III clinical trial for the reduction of docetaxel chemotherapy-induced severe, grade 4 neutropenia; a Phase II/III clinical trial for the prevention of non-docetaxel chemotherapy-induced severe, grade 4 neutropenia, and a Phase III clinical trial as an anticancer agent in combination with docetaxel in advanced non-small cell lung cancer (NSCLC). Plinabulin has also entered in a Phase I/II clinical trials to investigate its therapeutic potential in combination with the immuno-oncology agent nivolumab. The Company’s BPI-002 program is based on an oral small molecule agent, which induces T-cell activation. The Company’s IkappaB kinase (IKK) program, BPI-003, is based on a small molecule inhibitor of IKK, a protein kinase.

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